The pyruvate dehydrogenase complex is subject to allosteric control, especially inhibition by reaction products. From the list below, select the main regulatory processes controlling pyruvate dehydrogenase's activity in eukaryotes.

a. AMP binding to and activating the enzyme.
b. Phosphorylation by a kinase using ATP (which turns the complex off) and dephosphorylation by a phosphatase (which turns the complex on).
c. Exchange of ADP and ATP on the pyruvate dehydrogenase complex.
d. Phosphorylation by a kinase using ATP (which turns the complex on) and dephosphorylation by a phosphatase (which tums the complex off).

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